Hexaethylene glycol

Catalog	DGS2615158
CAS	2615-15-8
Structure
Description	Polyethylene glycol (PEG) compounds contain a polyether unit, commonly expressed as R1-(O-CH2-CH2)n-O-R2. They are generally biocompatible, non-toxic and stable in both organic and aqueous solutions, and so are extensively used in biological applications, as well as nanotechnology and materials research. Proteins with PEG chain modifications and compounds encapsulated in PEG liposomes exhibit a longer half-life in vivo than their non-PEGylated counterparts, a phenomenon known as PEG shielding. Functionalised PEG lipids and phospholipids can be used for protein-PEG conjugation.
Synonyms	3,6,9,12,15-Pentaoxaheptadecane-1,17-diol
IUPAC Name	2-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethanol
Molecular Weight	282.33
Molecular Formula	C12H26O7
Canonical SMILES	OCCOCCOCCOCCOCCOCCO
InChI	InChI=1S/C12H26O7/c13-1-3-15-5-7-17-9-11-19-12-10-18-8-6-16-4-2-14/h13-14H,1-12H2
InChI Key	IIRDTKBZINWQAW-UHFFFAOYSA-N
Boiling Point	217 °C at 4 mmHg (lit.)
Melting Point	5-7° C (lit.)
Purity	≥96%
Density	1.127 g/mL at 25 °C
Appearance	Liquid
Application	Activated PEG derivatives can be used to modify peptides, proteins, or in other bioconjugation applications. PEGylated materials have found broad use in drug delivery systems, virology, and immunology, as the incorporation of PEG improves pharmacological properties such as increased water solubility, enhanced resistance to degradation (protein hydrolysis), increased circulation half-life, and reduced antigenicity. In addition to PEGylation, activated PEG derivatives can also be used to form networks for tissue engineering or drug delivery applications, depending on the architecture and reactivity.
Complexity	141
EC Number	220-045-1
Exact Mass	282.16785316
Formal Charge	0
Heavy Atom Count	19
Hydrogen Bond Acceptor Count	7
Hydrogen Bond Donor Count	2
Isomeric SMILES	C(COCCOCCOCCOCCOCCO)O
MDL Number	MFCD00002877
Monoisotopic Mass	282.16785316
Rotatable Bond Count	16
Storage Conditions	Room temperature
Topological Polar Surface Area	86.6 Ų
XLogP3-AA	-1.9